IGVH Mutation Analysis by Sequencing
Order Name
IGVH MUT
Test Number: 6905049
Revision Date 12/12/2022
Test Number: 6905049
Revision Date 12/12/2022
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
IGVH Mutation Analysis by Sequencing
|
Polymerase Chain Reaction | 48670-4 |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 4 mL (0.5 mL) | Whole Blood | ||
| Alternate 1 | 5 mL (0.5 mL) | |||
| Instructions | Specimen Type: Peripheral blood or Bone Marrow; Lavender-top (EDTA) tube Specimen Storage: Maintain specimen at room temperature; STABLE for three to five days. Specimen Collection: Not Available Special Instructions: Testing referred to Accupath Diagnostic Laboratories ACCAZ#7327 Specimen Stability: Ambient: Not Available, Refrigerated : Not Available, Frozen: Not Available |
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| GENERAL INFORMATION | |
|---|---|
| Expected TAT | 6 - 8 days |
| Clinical Use | IgVH Somatic Hypermutation Determines the mutation status of IgVH gene in B lymphocytes, including those of CLL (chronic lymphocytic leukemia). The IgVH gene mutation status is one of the discriminators of clinical outcome in patients with CLL. The mutational status of the immunoglobulin genes expressed by CLL cells can be used to segregate patients into two subsets that have significantly different tendencies for disease progression. Patients with leukemic cells that express unmutated immunoglobulin heavy-chain variable region genes have a greater tendency for disease progression than those who have leukemic cells that express IgVH genes with less than 98% nucleic acid homology with their germ-line counterparts. |
| Performing Labcorp Test Code | 113753 |
| Notes | Labcorp Test Code: 113753 |
| CPT Code(s) | 81263 |
| Lab Section | Reference Lab |